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On MS-Windows the Middle Button / Wheel is also used for AutoScroll. In Firefox, this can be turned off / on by opening the page about:config Right-Click on general.autoScroll and select Toggle
On Linux / Unix systems the middle mouse button will also paste a URL into the address box. This can be changed by going to about:config and toggling middlemouse.contentLoadURL. Right and Left mouse buttons simultaneously circumvents this and I think also works in MS IE.
Since I only use Windows, and particularly IE, under duress, I cannot advise further in this area: perhaps you folk can. I will happily incorporate useful advice